The Faculty of Science and Engineering, Kasetsart University, Chalermphrakiat Sakon Nakhon Province Campus was established on June 8, 2000. At first, the faculty offered three curricula of engineering which were Machanical Engineering, Eletrical Engineering, and Civil Engineering. These curricula were the same of which at the Bangkhen Campus. In 2003 the faculty developed its owns curricula in order to replace the previous curricula. The new curricula were Machanical and Manufactural Engineering, Electrical and Computer Engineering, and Civil and Environmental Engineering.
            In 2004, the faculty offered a special program which was the Bachelor’s of Science in Information Technology. The curriculum was developed by the faculty of Liberal Arts and Science, Kampaengsaen Campus.
            In 2007 the faculty offeed a special program of Electrical and Computer Engineering. Moreover, in 2008 the special program of Cicil and Environmental Egineering was developed to serve the need of the region